Mitochondrial Channels and Their Role in Cardioprotection

Mitochondria play a pivotal role in cardioprotection. The major cardioprotective mechanism is ischemic preconditioning (IpreC), through which short periods of ischemia protect subsequent prolonged acute episode. channels, particularly the potassium channels (mitoK) such as ATP-dependent and calcium-activated have been suggested trigger or end effectors IpreC. Activators mitoK are promising therapeutic agents for treatment myocardial injury due to episodes. In this chapter, we summarizing our current knowledge on physiology function different mitochondrial with focus their Furthermore, currently under development therapy by targeting heart failure also discussed.